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Structural requirements of bile acid transporters: C-3 and C-7 modifications of steroidal hydroxyl groups

The apical sodium dependent bile acid transporter (ASBT) and sodium-taurocholate cotransporting polypeptide (NTCP) are potential prodrug targets, but the structural requirements for these transporters are incompletely defined. The objective of this study was to evaluate the effect of C-3 and C-7 sub...

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Détails bibliographiques
Auteurs principaux: Kolhatkar, Vidula, Polli, James E.
Format: Artigo
Langue:Inglês
Publié: 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319149/
https://ncbi.nlm.nih.gov/pubmed/22387310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejps.2012.02.012
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