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Beta-arrestin-2 regulates cannabinoid CB(1) receptor signaling and adaptation in a CNS region-dependent manner
BACKGROUND: Cannabinoid CB(1) receptors (CB(1)R) mediate the effects of Δ(9)-tetrahydrocannabinol (THC), the psychoactive component in marijuana. Repeated THC administration produces tolerance and dependence, which limit therapeutic development. Moreover, THC produces motor and psychoactive side eff...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3319102/ https://ncbi.nlm.nih.gov/pubmed/22264443 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2011.11.027 |
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