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Calpastatin modulates APP processing in the brains of β-amyloid depositing but not wild-type mice

We report that neuronal overexpression of the endogenous inhibitor of calpains, calpastatin (CAST), in a mouse model of human Alzheimer’s disease (AD) β-amyloidosis, the APP23 mouse, reduces β-amyloid pathology and Aβ levels when comparing aged, double transgenic (tg) APP23/CAST with APP23 mice. Con...

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Autors principals: Morales-Corraliza, Jose, Berger, Jason D, Mazzella, Matthew J, Veeranna, Neubert, Thomas A., Ghiso, Jorge, Rao, Mala V, Staufenbiel, Matthias, Nixon, Ralph A, Mathews, Paul M
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318946/
https://ncbi.nlm.nih.gov/pubmed/22206846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.11.023
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