Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model

While anti-human-Aβ immunotherapy clears brain β-amyloid plaques in Alzheimer's disease (AD), targeting additional brain plaque constituents to promote clearance has not been attempted. Endogenous murine Aβ is a minor β-amyloid plaque component in amyloid precursor protein transgenic AD models,...

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Detalhes bibliográficos
Main Authors: Morales-Corraliza, Jose, Schmidt, Stephen D., Mazzella, Matthew J., Berger, Jason D., Wilson, Donald A., Wesson, Daniel W., Jucker, Mathias, Levy, Efrat, Nixon, Ralph A., Mathews, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3426627/
https://ncbi.nlm.nih.gov/pubmed/22608241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2012.04.007
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