In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Aβ and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In spi...

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Detalhes bibliográficos
Main Authors: Morales-Corraliza, Jose, Mazzella, Matthew J., Berger, Jason D., Diaz, Nicole S., Choi, Jennifer H. K., Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741602/
https://ncbi.nlm.nih.gov/pubmed/19771166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007134
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