In Vivo Turnover of Tau and APP Metabolites in the Brains of Wild-Type and Tg2576 Mice: Greater Stability of sAPP in the β-Amyloid Depositing Mice

The metabolism of the amyloid precursor protein (APP) and tau are central to the pathobiology of Alzheimer's disease (AD). We have examined the in vivo turnover of APP, secreted APP (sAPP), Aβ and tau in the wild-type and Tg2576 mouse brain using cycloheximide to block protein synthesis. In spi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Morales-Corraliza, Jose, Mazzella, Matthew J., Berger, Jason D., Diaz, Nicole S., Choi, Jennifer H. K., Levy, Efrat, Matsuoka, Yasuji, Planel, Emmanuel, Mathews, Paul M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741602/
https://ncbi.nlm.nih.gov/pubmed/19771166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007134
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge