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Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity
The principle virulence factors in Clostridium difficile pathogenesis are TcdA and TcdB, homologous glucosyltransferases capable of inactivating small GTPases within the host cell. We present crystal structures of the TcdA glucosyltransferase domain in the presence and absence of the co-substrate UD...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318759/ https://ncbi.nlm.nih.gov/pubmed/22267739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.298414 |
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