Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity

The principle virulence factors in Clostridium difficile pathogenesis are TcdA and TcdB, homologous glucosyltransferases capable of inactivating small GTPases within the host cell. We present crystal structures of the TcdA glucosyltransferase domain in the presence and absence of the co-substrate UD...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pruitt, Rory N., Chumbler, Nicole M., Rutherford, Stacey A., Farrow, Melissa A., Friedman, David B., Spiller, Ben, Lacy, D. Borden
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2012
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318759/
https://ncbi.nlm.nih.gov/pubmed/22267739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.298414
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