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Structural Determinants of Clostridium difficile Toxin A Glucosyltransferase Activity

The principle virulence factors in Clostridium difficile pathogenesis are TcdA and TcdB, homologous glucosyltransferases capable of inactivating small GTPases within the host cell. We present crystal structures of the TcdA glucosyltransferase domain in the presence and absence of the co-substrate UD...

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Bibliografiske detaljer
Main Authors: Pruitt, Rory N., Chumbler, Nicole M., Rutherford, Stacey A., Farrow, Melissa A., Friedman, David B., Spiller, Ben, Lacy, D. Borden
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318759/
https://ncbi.nlm.nih.gov/pubmed/22267739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.298414
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