Identification of Residues That Underpin Interactions within the Eukaryotic Initiation Factor (eIF2) 2B Complex

Eukaryotic initiation factor 2B (eIF2B) plays a key role in protein synthesis and in its control. It comprises five different subunits, α-ϵ, of which eIF2Bϵ contains the catalytic domain. Formation of the complete complex is crucial for full activity and proper control of eIF2B. Mutations in the gen...

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Bibliographic Details
Main Authors: Wang, Xuemin, Wortham, Noel C., Liu, Rui, Proud, Christopher G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318736/
https://ncbi.nlm.nih.gov/pubmed/22238342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.331553
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