Cross-Reactivity of Antipneumococcal Surface Protein C (PspC) Antibodies with Different Strains and Evaluation of Inhibition of Human Complement Factor H and Secretory IgA Binding via PspC

Pneumococcal surface protein C (PspC) is an important candidate for a cost-effective vaccine with broad coverage against pneumococcal diseases. Previous studies have shown that Streptococcus pneumoniae is able to bind to both human factor H (FH), an inhibitor of complement alternative pathway, and h...

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Main Authors: Moreno, Adriana T., Oliveira, Maria Leonor S., Ho, Paulo L., Vadesilho, Cintia F. M., Palma, Giovana M. P., Ferreira, Jorge M. C., Ferreira, Daniela M., Santos, Silvia R., Martinez, Marina B., Miyaji, Eliane N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2012
Assuntos:
Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318277/
https://ncbi.nlm.nih.gov/pubmed/22336290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05706-11
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