Cross-Reactivity of Antipneumococcal Surface Protein C (PspC) Antibodies with Different Strains and Evaluation of Inhibition of Human Complement Factor H and Secretory IgA Binding via PspC

Pneumococcal surface protein C (PspC) is an important candidate for a cost-effective vaccine with broad coverage against pneumococcal diseases. Previous studies have shown that Streptococcus pneumoniae is able to bind to both human factor H (FH), an inhibitor of complement alternative pathway, and h...

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Autori principali: Moreno, Adriana T., Oliveira, Maria Leonor S., Ho, Paulo L., Vadesilho, Cintia F. M., Palma, Giovana M. P., Ferreira, Jorge M. C., Ferreira, Daniela M., Santos, Silvia R., Martinez, Marina B., Miyaji, Eliane N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318277/
https://ncbi.nlm.nih.gov/pubmed/22336290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.05706-11
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