Characterization of Protective Mucosal and Systemic Immune Responses Elicited by Pneumococcal Surface Protein PspA and PspC Nasal Vaccines against a Respiratory Pneumococcal Challenge in Mice

Pneumococcal surface protein A (PspA) and PspC are virulence factors that are involved in the adhesion of Streptococcus pneumoniae to epithelial cells and/or evasion from the immune system. Here, the immune responses induced by mucosal vaccines composed of both antigens as recombinant proteins or de...

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Main Authors: Ferreira, D. M., Darrieux, M., Silva, D. A., Leite, L. C. C., Ferreira, J. M. C., Ho, P. L., Miyaji, E. N., Oliveira, M. L. S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Vaccine Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681601/
https://ncbi.nlm.nih.gov/pubmed/19279169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00395-08
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