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pH-Responsive Titratable Inotropic Performance of Histidine-Modified Cardiac Troponin I
Cardiac troponin I (cTnI) functions as the molecular switch of the thin filament. Studies have shown that a histidine button engineered into cTnI (cTnI A164H) specifically enhances inotropic function in the context of numerous pathophysiological challenges. To gain mechanistic insight into the basis...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3318134/ https://ncbi.nlm.nih.gov/pubmed/22500757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.024 |
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