Two Different Binding Modes of α-Synuclein to Lipid Vesicles Depending on its Aggregation State

Aggregation of α-synuclein is involved in the pathogenesis of Parkinson's disease (PD). Studies of in vitro aggregation of α-synuclein are rendered complex because of the formation of a heterogeneous population of oligomers. With the use of confocal single-molecule fluorescence techniques, we d...

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Bibliografiske detaljer
Main Authors: Högen, Tobias, Levin, Johannes, Schmidt, Felix, Caruana, Mario, Vassallo, Neville, Kretzschmar, Hans, Bötzel, Kai, Kamp, Frits, Giese, Armin
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2012
Fag:
Spectroscopy, Imaging, and Other Techniques
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318129/
https://ncbi.nlm.nih.gov/pubmed/22500765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.01.059
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