Somatostatin Modulates Insulin-Degrading-Enzyme Metabolism: Implications for the Regulation of Microglia Activity in AD

The deposition of β-amyloid (Aβ) into senile plaques and the impairment of somatostatin-mediated neurotransmission are key pathological events in the onset of Alzheimer's disease (AD). Insulin-degrading-enzyme (IDE) is one of the main extracellular protease targeting Aβ, and thus it represents...

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Autori principali: Tundo, Grazia, Ciaccio, Chiara, Sbardella, Diego, Boraso, Mariaserena, Viviani, Barbara, Coletta, Massimiliano, Marini, Stefano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317975/
https://ncbi.nlm.nih.gov/pubmed/22509294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034376
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