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Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme

Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and Alzheimer's disease. We examined the thiol sensitivity of IDE using S-nitrosoglutathione, reduced glutathione, and oxidized glutathione to disti...

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Bibliografske podrobnosti
Main Authors: Cordes, Crystal M., Bennett, Robert G., Siford, Gerri L., Hamel, Frederick G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3063182/
https://ncbi.nlm.nih.gov/pubmed/21448434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018138
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