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Redox Regulation of Insulin Degradation by Insulin-Degrading Enzyme
Insulin-degrading enzyme (IDE) is a thiol sensitive peptidase that degrades insulin and amyloid β, and has been linked to type 2 diabetes mellitus and Alzheimer's disease. We examined the thiol sensitivity of IDE using S-nitrosoglutathione, reduced glutathione, and oxidized glutathione to disti...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3063182/ https://ncbi.nlm.nih.gov/pubmed/21448434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018138 |
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