Proteasome Activity Is Affected by Fluctuations in Insulin-Degrading Enzyme Distribution

Insulin-Degrading-Enzyme (IDE) is a Zn(2+)-dependent peptidase highly conserved throughout evolution and ubiquitously distributed in mammalian tissues wherein it displays a prevalent cytosolic localization. We have recently demonstrated a novel Heat Shock Protein-like behaviour of IDE and its associ...

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Veröffentlicht in:PLoS One
Hauptverfasser: Sbardella, Diego, Tundo, Grazia Raffaella, Sciandra, Francesca, Bozzi, Manuela, Gioia, Magda, Ciaccio, Chiara, Tarantino, Umberto, Brancaccio, Andrea, Coletta, Massimo, Marini, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4506093/
https://ncbi.nlm.nih.gov/pubmed/26186340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132455
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