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Rara haploinsufficiency modestly influences the phenotype of acute promyelocytic leukemia in mice

RARA (retinoic acid receptor alpha) haploinsufficiency is an invariable consequence of t(15;17)(q22;q21) translocations in acute promyelocytic leukemia (APL). Retinoids and RARA activity have been implicated in hematopoietic self-renewal and neutrophil maturation. We and others therefore predicted t...

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Sonraí Bibleagrafaíochta
Main Authors: Welch, John S., Klco, Jeffery M., Varghese, Nobish, Nagarajan, Rakesh, Ley, Timothy J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317790/
https://ncbi.nlm.nih.gov/pubmed/21190992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-08-300087
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