High shear–dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction

Platelets have evolved a highly specialized membrane skeleton that provides stability to the plasma membrane and facilitates adhesion under high shear stress. The cytoskeletal anchorage of glycoprotein (GP) Ibα plays an important role in regulating the membrane skeleton. However, its role in regulat...

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Bibliographic Details
Main Authors: Cranmer, Susan L., Ashworth, Katrina J., Yao, Yu, Berndt, Michael C., Ruggeri, Zaverio M., Andrews, Robert K., Jackson, Shaun P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317769/
https://ncbi.nlm.nih.gov/pubmed/21156842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-296194
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