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High shear–dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction
Platelets have evolved a highly specialized membrane skeleton that provides stability to the plasma membrane and facilitates adhesion under high shear stress. The cytoskeletal anchorage of glycoprotein (GP) Ibα plays an important role in regulating the membrane skeleton. However, its role in regulat...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3317769/ https://ncbi.nlm.nih.gov/pubmed/21156842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-07-296194 |
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