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An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY

The SecY/Sec61α family of membrane proteins are the central subunits of the putative protein translocation channel. We introduced random mutations into a segment of Escherichia coli SecY within its cytoplasmic domain 5, which was shown previously to be important for the SecA-dependent translocation...

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Autors principals: Mori, Hiroyuki, Ito, Koreaki
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 2001
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC33175/
https://ncbi.nlm.nih.gov/pubmed/11309495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081617398
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