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An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY
The SecY/Sec61α family of membrane proteins are the central subunits of the putative protein translocation channel. We introduced random mutations into a segment of Escherichia coli SecY within its cytoplasmic domain 5, which was shown previously to be important for the SecA-dependent translocation...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33175/ https://ncbi.nlm.nih.gov/pubmed/11309495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081617398 |
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