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An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY
The SecY/Sec61α family of membrane proteins are the central subunits of the putative protein translocation channel. We introduced random mutations into a segment of Escherichia coli SecY within its cytoplasmic domain 5, which was shown previously to be important for the SecA-dependent translocation...
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| Main Authors: | , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The National Academy of Sciences
2001
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33175/ https://ncbi.nlm.nih.gov/pubmed/11309495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.081617398 |
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