An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

Developmental genes are regulated by complex, distantly located cis-regulatory modules (CRMs), often forming genomic regulatory blocks (GRBs) that are conserved among vertebrates and among insects. We have investigated GRBs associated with Iroquois homeobox genes in 39 metazoans. Despite 600 million...

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Main Authors: Maeso, Ignacio, Irimia, Manuel, Tena, Juan J., González-Pérez, Esther, Tran, David, Ravi, Vydianathan, Venkatesh, Byrappa, Campuzano, Sonsoles, Gómez-Skarmeta, José Luis, Garcia-Fernàndez, Jordi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2012
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317147/
https://ncbi.nlm.nih.gov/pubmed/22234889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.132233.111
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