Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints

The order of genes in eukaryotic genomes has generally been assumed to be neutral, since gene order is largely scrambled over evolutionary time. Only a handful of exceptional examples are known, typically involving deeply conserved clusters of tandemly duplicated genes (e.g., Hox genes and histones)...

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Main Authors: Irimia, Manuel, Tena, Juan J., Alexis, Maria S., Fernandez-Miñan, Ana, Maeso, Ignacio, Bogdanović, Ozren, de la Calle-Mustienes, Elisa, Roy, Scott W., Gómez-Skarmeta, José L., Fraser, Hunter B.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2012
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3514665/
https://ncbi.nlm.nih.gov/pubmed/22722344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.139725.112
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