An ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacement

Developmental genes are regulated by complex, distantly located cis-regulatory modules (CRMs), often forming genomic regulatory blocks (GRBs) that are conserved among vertebrates and among insects. We have investigated GRBs associated with Iroquois homeobox genes in 39 metazoans. Despite 600 million...

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Autors principals: Maeso, Ignacio, Irimia, Manuel, Tena, Juan J., González-Pérez, Esther, Tran, David, Ravi, Vydianathan, Venkatesh, Byrappa, Campuzano, Sonsoles, Gómez-Skarmeta, José Luis, Garcia-Fernàndez, Jordi
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317147/
https://ncbi.nlm.nih.gov/pubmed/22234889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.132233.111
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