Glutathione-dependent reductive stress triggers mitochondrial oxidation and cytotoxicity

To investigate the effects of the predominant nonprotein thiol, glutathione (GSH), on redox homeostasis, we employed complementary pharmacological and genetic strategies to determine the consequences of both loss- and gain-of-function GSH content in vitro. We monitored the redox events in the cytoso...

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Main Authors: Zhang, Huali, Limphong, Pattraranee, Pieper, Joel, Liu, Qiang, Rodesch, Christopher K., Christians, Elisabeth, Benjamin, Ivor J.
格式: Artigo
語言:Inglês
出版: Federation of American Societies for Experimental Biology 2012
主題:
Research Communications
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316899/
https://ncbi.nlm.nih.gov/pubmed/22202674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-199869
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