Aggregate-Prone R120GCRYAB Triggers Multifaceted Modifications of the Thioredoxin System

Aims: The human mutation R120G in the αB-crystallin (CRYAB) causes a multisystemic disease that is characterized by hypertrophic cardiomyopathy and cytoplasmic protein aggregates. In transgenic mice, human R120GCRYAB (hR120GTg) expression in heart sequentially modifies the REDOX status, in part by t...

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Hlavní autoři: Banerjee Mustafi, Soumyajit, Grose, Julianne H., Zhang, Huali, Pratt, Gregory W., Sadoshima, Junichi, Christians, Elisabeth S., Benjamin, Ivor J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2014
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4039002/
https://ncbi.nlm.nih.gov/pubmed/24180415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5340
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