Dysregulation of Glutathione Homeostasis Causes Oxido-reductive Stress and Cardiomyopathy in R120GCryAB Mice

Oxidative stress is widely implicated in pathogenic states including heart failure. In contrast, the role of ‘reductive stress,’ defined as the abnormal increase of reducing equivalents (e.g., glutathione, NADPH), remains controversial. Here we show that transgenic mice overexpressing cardiac-specif...

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Main Authors: Rajasekaran, Namakkal S., Connell, Patrice, Christians, Elisabeth S., Yan, Liang-Jun, Taylor, Ryan P., Orosz, Andras, Zhang, Xia Q., Stevenson, Tamara J., Peshock, Ronald M., Leopold, Jane A., Barry, William H., Loscalzo, Joseph, Odelberg, Shannon J., Benjamin, Ivor J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962423/
https://ncbi.nlm.nih.gov/pubmed/17693254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2007.06.044
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