Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine

ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a prototype for Cys-loop receptors. Here we show that acetylcholine is a competitive antagonist for ELIC. We determine the acetylcholine–ELIC cocrystal structure to a 2.9-Å resolution and find that acetylcholine binding to a...

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Main Authors: Pan, Jianjun, Chen, Qiang, Willenbring, Dan, Yoshida, Ken, Tillman, Tommy, Kashlan, Ossama B., Cohen, Aina, Kong, Xiang-Peng, Xu, Yan, Tang, Pei
Formato: Artigo
Idioma:Inglês
Publicado: Nature Pub. Group 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316889/
https://ncbi.nlm.nih.gov/pubmed/22395605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1703
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