Xylosyltransferase-I Regulates Glycosaminoglycan Synthesis during the Pathogenic Process of Human Osteoarthritis

Loss of glycosaminoglycan (GAG) chains of proteoglycans (PGs) is an early event of osteoarthritis (OA) resulting in cartilage degradation that has been previously demonstrated in both huma and experimental OA models. However, the mechanism of GAG loss and the role of xylosyltransferase-I (XT-I) that...

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Hauptverfasser: Venkatesan, Narayanan, Barré, Lydia, Bourhim, Mustapha, Magdalou, Jacques, Mainard, Didier, Netter, Patrick, Fournel-Gigleux, Sylvie, Ouzzine, Mohamed
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3316535/
https://ncbi.nlm.nih.gov/pubmed/22479506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034020
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