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Targeting of Proteoglycan Synthesis Pathway: A New Strategy to Counteract Excessive Matrix Proteoglycan Deposition and Transforming Growth Factor-β1-Induced Fibrotic Phenotype in Lung Fibroblasts

Stimulation of proteoglycan (PG) synthesis and deposition plays an important role in the pathophysiology of fibrosis and is an early and dominant feature of pulmonary fibrosis. Transforming growth factor-β1 (TGF-β1) is a major cytokine associated with fibrosis that induces excessive synthesis of mat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Shaukat, Irfan, Barré, Lydia, Venkatesan, Narayanan, Li, Dong, Jaquinet, Jean-Claude, Fournel-Gigleux, Sylvie, Ouzzine, Mohamed
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4709117/
https://ncbi.nlm.nih.gov/pubmed/26751072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0146499
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