Semi-Synthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation

The process of neurodegeneration in Parkinson’s Disease is intimately associated with the aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of these protein aggregates are found to be posttranslationally modified by ubiquitin at several different lysine res...

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Main Authors: Meier, Franziska, Abeywardana, Tharindumala, Dhall, Abhinav, Marotta, Nicholas P., Varkey, Jobin, Langen, Ralf, Chatterjee, Champak, Pratt, Matthew R.
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315850/
https://ncbi.nlm.nih.gov/pubmed/22404520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja300094r
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