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Synthetic and semi-synthetic strategies to study ubiquitin signaling

The post-translational modification ubiquitin can be attached to the ɛ-amino group of lysine residues or to a protein's N-terminus as a mono ubiquitin moiety. Via its seven intrinsic lysine residues and its N-terminus, it can also form ubiquitin chains on substrates in many possible ways. To st...

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Bibliographic Details
Published in:Curr Opin Struct Biol
Main Authors: van Tilburg, Gabriëlle BA, Elhebieshy, Angela F, Ovaa, Huib
Format: Artigo
Language:Inglês
Published: Elsevier Ltd. 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7125694/
https://ncbi.nlm.nih.gov/pubmed/27315041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sbi.2016.05.022
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