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Semi-Synthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation
The process of neurodegeneration in Parkinson’s Disease is intimately associated with the aggregation of the protein α-synuclein into toxic oligomers and fibrils. Interestingly, many of these protein aggregates are found to be posttranslationally modified by ubiquitin at several different lysine res...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315850/ https://ncbi.nlm.nih.gov/pubmed/22404520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja300094r |
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