O-GlcNAc modification blocks the aggregation and toxicity of the Parkinson’s disease associated protein α-synuclein

Several aggregation-prone proteins associated with neurodegenerative diseases can be modified by O-linked N-acetyl-glucosamine (O-GlcNAc) in vivo. One of these proteins, α-synuclein, is a toxic aggregating-protein associated with synucleinopathies, including Parkinson’s disease. However, the effect...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Marotta, Nicholas P., Lin, Yu Hsuan, Lewis, Yuka E., Ambroso, Mark R., Zaro, Balyn W., Roth, Maxwell T., Arnold, Don B., Langen, Ralf, Pratt, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4618406/
https://ncbi.nlm.nih.gov/pubmed/26492012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchem.2361
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