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The Small Molecule 2‑Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O‑GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O‑GlcNAc Transferase

Glycans can be directly labeled using unnatural monosaccharide analogs, termed metabolic chemical reporters (MCRs). These compounds enable the secondary visualization and identification of glycoproteins by taking advantage of bioorthogonal reactions. Most widely used MCRs have azides or alkynes at t...

詳細記述

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書誌詳細
出版年:ACS Chem Biol
主要な著者: Zaro, Balyn W., Batt, Anna R., Chuh, Kelly N., Navarro, Marisol X., Pratt, Matthew R.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223259/
https://ncbi.nlm.nih.gov/pubmed/28135057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00877
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