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The Small Molecule 2‑Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O‑GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O‑GlcNAc Transferase

Glycans can be directly labeled using unnatural monosaccharide analogs, termed metabolic chemical reporters (MCRs). These compounds enable the secondary visualization and identification of glycoproteins by taking advantage of bioorthogonal reactions. Most widely used MCRs have azides or alkynes at t...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Zaro, Balyn W., Batt, Anna R., Chuh, Kelly N., Navarro, Marisol X., Pratt, Matthew R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223259/
https://ncbi.nlm.nih.gov/pubmed/28135057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00877
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