The Small Molecule 2‑Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O‑GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O‑GlcNAc Transferase

Glycans can be directly labeled using unnatural monosaccharide analogs, termed metabolic chemical reporters (MCRs). These compounds enable the secondary visualization and identification of glycoproteins by taking advantage of bioorthogonal reactions. Most widely used MCRs have azides or alkynes at t...

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Publicado en:ACS Chem Biol
Autores principales: Zaro, Balyn W., Batt, Anna R., Chuh, Kelly N., Navarro, Marisol X., Pratt, Matthew R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6223259/
https://ncbi.nlm.nih.gov/pubmed/28135057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b00877
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