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The allele distribution in next-generation sequencing data sets is accurately described as the result of a stochastic branching process
With the availability of next-generation sequencing (NGS) technology, it is expected that sequence variants may be called on a genomic scale. Here, we demonstrate that a deeper understanding of the distribution of the variant call frequencies at heterozygous loci in NGS data sets is a prerequisite f...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3315291/ https://ncbi.nlm.nih.gov/pubmed/22127862 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1073 |
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