The allele distribution in next-generation sequencing data sets is accurately described as the result of a stochastic branching process

With the availability of next-generation sequencing (NGS) technology, it is expected that sequence variants may be called on a genomic scale. Here, we demonstrate that a deeper understanding of the distribution of the variant call frequencies at heterozygous loci in NGS data sets is a prerequisite f...

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Bibliografiske detaljer
Main Authors: Heinrich, Verena, Stange, Jens, Dickhaus, Thorsten, Imkeller, Peter, Krüger, Ulrike, Bauer, Sebastian, Mundlos, Stefan, Robinson, Peter N., Hecht, Jochen, Krawitz, Peter M.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Computational Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315291/
https://ncbi.nlm.nih.gov/pubmed/22127862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr1073
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