LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

The leucine-rich repeat kinase 2 (LRRK2) mutations are the most common cause of autosomal-dominant Parkinson disease (PD). Mitochondrial dysfunction represents a critical event in the pathogenesis of PD. We demonstrated that wild-type (WT) LRRK2 expression caused mitochondrial fragmentation along wi...

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Autors principals: Wang, Xinglong, Yan, Michael H., Fujioka, Hisashi, Liu, Jun, Wilson-Delfosse, Amy, Chen, Shu G., Perry, George, Casadesus, Gemma, Zhu, Xiongwei
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3315202/
https://ncbi.nlm.nih.gov/pubmed/22228096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/dds003
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