Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

Mitochondrial dysfunction represents a critical step during the pathogenesis of Parkinson disease (PD) and increasing evidence suggests abnormal mitochondrial dynamics and quality control as important underlying mechanisms. The VPS35 gene, encoding a key component of the retromer complex, is the thi...

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Publicado en:Nat Med
Autores principales: Wang, Wenzhang, Wang, Xinglong, Fujioka, Hisashi, Hoppel, Charles, Whone, Alan L., Caldwell, Maeve A., Cullen, Peter J., Liu, Jun, Zhu, Xiongwei
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4826611/
https://ncbi.nlm.nih.gov/pubmed/26618722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3983
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