Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

Mitochondrial dysfunction is a prominent feature of Alzheimer disease but the underlying mechanism is unclear. In this study, we investigated the effect of amyloid precursor protein (APP) and amyloid β on mitochondrial dynamics in neurons. Confocal and electron microscopic analysis demonstrated that...

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Autori principali: Wang, Xinglong, Su, Bo, Siedlak, Sandra L., Moreira, Paula I., Fujioka, Hisashi, Wang, Yang, Casadesus, Gemma, Zhu, Xiongwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614759/
https://ncbi.nlm.nih.gov/pubmed/19050078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0804871105
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