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Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism

Effective antiviral agents are thought to inhibit hepatitis B virus (HBV) DNA synthesis irreversibly by chain termination because reverse transcriptases (RT) lack an exonucleolytic activity that can remove incorporated nucleotides. However, since the parameters governing this inhibition are poorly d...

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Sonraí Bibleagrafaíochta
Main Authors: Urban, Sinisa, Urban, Severin, Fischer, Karl P., Tyrrell, D. Lorne
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2001
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC33150/
https://ncbi.nlm.nih.gov/pubmed/11320247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091324398
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