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Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism
Effective antiviral agents are thought to inhibit hepatitis B virus (HBV) DNA synthesis irreversibly by chain termination because reverse transcriptases (RT) lack an exonucleolytic activity that can remove incorporated nucleotides. However, since the parameters governing this inhibition are poorly d...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2001
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC33150/ https://ncbi.nlm.nih.gov/pubmed/11320247 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.091324398 |
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