Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

BACKGROUND: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidit...

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Detalles Bibliográficos
Autores principales: Martin, N K, Robey, I F, Gaffney, E A, Gillies, R J, Gatenby, R A, Maini, P K
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2012
Materias:
Translational Therapeutics
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314784/
https://ncbi.nlm.nih.gov/pubmed/22382688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.58
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