Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study

BACKGROUND: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose metabolism when compared with adjacent normal tissue, resulting in an acidic tumour microenvironment. Recent studies demonstrated reducing this acidit...

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Detalhes bibliográficos
Main Authors: Martin, N K, Robey, I F, Gaffney, E A, Gillies, R J, Gatenby, R A, Maini, P K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314784/
https://ncbi.nlm.nih.gov/pubmed/22382688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.58
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