Amyloid Precursor Protein (APP) Mediated Regulation of Ganglioside Homeostasis Linking Alzheimer's Disease Pathology with Ganglioside Metabolism

Gangliosides are important players for controlling neuronal function and are directly involved in AD pathology. They are among the most potent stimulators of Aβ production, are enriched in amyloid plaques and bind amyloid beta (Aβ). However, the molecular mechanisms linking gangliosides with AD are...

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Hauptverfasser: Grimm, Marcus O. W., Zinser, Eva G., Grösgen, Sven, Hundsdörfer, Benjamin, Rothhaar, Tatjana L., Burg, Verena K., Kaestner, Lars, Bayer, Thomas A., Lipp, Peter, Müller, Ulrike, Grimm, Heike S., Hartmann, Tobias
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314703/
https://ncbi.nlm.nih.gov/pubmed/22470521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034095
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