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Rapamycin Ameliorates Kidney Fibrosis by Inhibiting the Activation of mTOR Signaling in Interstitial Macrophages and Myofibroblasts

Interstitial fibrosis is an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). Emerging data indicate that rapamycin can ameliorate kidney fibrosis by reducing the interstitial infiltrates and accumulation of extra cellular matrix (ECM). However, the cellular mechanism that...

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Detalhes bibliográficos
Main Authors: Chen, Guochun, Chen, Huihui, Wang, Chang, Peng, Youming, Sun, Lin, Liu, Hong, Liu, Fuyou
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314672/
https://ncbi.nlm.nih.gov/pubmed/22470459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033626
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