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Chromosomal instability and cancer: a complex relationship with therapeutic potential

Chromosomal instability (CIN) is a hallmark of human neoplasms. Despite its widespread prevalence, knowledge of the mechanisms and contributions of CIN in cancer has been elusive. It is now evident that the role of CIN in tumor initiation and growth is more complex than previously thought. Furthermo...

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Библиографические подробности
Главные авторы: Bakhoum, Samuel F., Compton, Duane A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3314464/
https://ncbi.nlm.nih.gov/pubmed/22466654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI59954
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